1J7V

HUMAN IL-10 / IL-10R1 COMPLEX

1J7V の概要

• エントリーDOI: 10.2210/pdb1j7v/pdb
• 分子名称: INTERLEUKIN-10, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN (3 entities in total)
• 機能のキーワード: cytokine receptor complex, 4 helix bundle, class 2 receptor, interleukin-10, cytokine-receptor complex, cytokine/receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P22301; Membrane; Single-pass type I membrane protein: Q13651
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43179.00

構造登録者

Josephson, K.,Logsdon, N.,Walter, M.R. (登録日: 2001-05-18, 公開日: 2001-09-19, 最終更新日: 2024-10-30)

主引用文献

Josephson, K.,Logsdon, N.J.,Walter, M.R.
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.
Immunity, 15:35-46, 2001

PubMed Abstract: Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.

PubMed: 11485736
DOI: 10.1016/S1074-7613(01)00169-8

実験手法

X-RAY DIFFRACTION (2.9 Å)