1J42

Crystal Structure of Human DJ-1

1J42 の概要

• エントリーDOI: 10.2210/pdb1j42/pdb
• 分子名称: RNA-binding protein regulatory subunit (2 entities in total)
• 機能のキーワード: parkinson's disease, rna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Lipid-anchor : Q99497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19873.02

構造登録者

Cha, S.S. (登録日: 2003-02-26, 公開日: 2004-02-03, 最終更新日: 2023-12-27)

主引用文献

Lee, S.J.,Kim, S.J.,Kim, I.K.,Ko, J.,Jeong, C.S.,Kim, G.H.,Park, C.,Kang, S.O.,Suh, P.G.,Lee, H.S.,Cha, S.S.
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
J.Biol.Chem., 278:44552-44559, 2003

PubMed Abstract: Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.

PubMed: 12939276
DOI: 10.1074/jbc.M304517200

実験手法

X-RAY DIFFRACTION (2.5 Å)