1ITY

Solution structure of the DNA binding domain of human TRF1

1ITY の概要

• エントリーDOI: 10.2210/pdb1ity/pdb
• 関連するPDBエントリー: 1ba5
• NMR情報: BMRB: 5317
• 分子名称: TRF1 (1 entity in total)
• 機能のキーワード: helix-turn-helix, telomeres, dna binding, myb domain, riken structural genomics/proteomics initiative, rsgi, structural genomics, dna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P54274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8467.75

構造登録者

Nishikawa, T.,Okamura, H.,Nagadoi, A.,Konig, P.,Rhodes, D.,Nishimura, Y.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2002-02-15, 公開日: 2002-03-06, 最終更新日: 2023-12-27)

主引用文献

Nishikawa, T.,Okamura, H.,Nagadoi, A.,Konig, P.,Rhodes, D.,Nishimura, Y.
Solution structure of a telomeric DNA complex of human TRF1
Structure, 9:1237-1251, 2001

PubMed Abstract: Mammalian telomeres consist of long tandem arrays of double-stranded TTAGGG sequence motif packaged by TRF1 and TRF2. In contrast to the DNA binding domain of c-Myb, which consists of three imperfect tandem repeats, DNA binding domains of both TRF1 and TRF2 contain only a single Myb repeat. In a DNA complex of c-Myb, both the second and third repeats are closely packed in the major groove of DNA and recognize a specific base sequence cooperatively.

PubMed: 11738049
DOI: 10.1016/S0969-2126(01)00688-8

実験手法

SOLUTION NMR