1IRR

Solution structure of paralytic peptide of the silkworm, Bombyx mori

1IRR の概要

• エントリーDOI: 10.2210/pdb1irr/pdb
• NMR情報: BMRB: 5188
• 分子名称: paralytic peptide (1 entity in total)
• 機能のキーワード: single beta sheet, cytokine
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2466.79

構造登録者

Miura, K.,Kamimura, M.,Aizawa, T.,Kiuchi, M.,Hayakawa, Y.,Mizuguchi, M.,Kawano, K. (登録日: 2001-10-23, 公開日: 2003-02-11, 最終更新日: 2024-10-30)

主引用文献

Miura, K.,Kamimura, M.,Aizawa, T.,Kiuchi, M.,Hayakawa, Y.,Mizuguchi, M.,Kawano, K.
Solution structure of paralytic peptide of silkworm, Bombyx mori
peptides, 23:2111-2116, 2002

PubMed Abstract: Paralytic peptide of Bombyx mori (BmPP) is one of the multifunctional ENF-peptides; the name of "ENF" is the consensus N-terminal amino acid sequence of the family peptides. We revealed that BmPP significantly possesses growth-blocking activity and plasmatocyte-spreading activity and that its activity profiles are different from those of another ENF-family peptide, namely, the growth-blocking peptide of Pseudaletia separata (PsGBP). We also determined the NMR structures of BmPP and PsGBP under the same conditions, which revealed the structural differences of the first and second beta-turn regions between the two peptides. On the basis of our results, it can be considered that the tertiary structural difference in these peptides may cause their different profiles of growth-blocking activity.

PubMed: 12535689
DOI: 10.1016/S0196-9781(02)00254-1

実験手法

SOLUTION NMR