1IOD

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE COAGULATION FACTOR X BINDING PROTEIN FROM SNAKE VENOM AND THE GLA DOMAIN OF FACTOR X

1IOD の概要

• エントリーDOI: 10.2210/pdb1iod/pdb
• 関連するPDBエントリー: 1BJ3 1IXX
• 分子名称: COAGULATION FACTOR X BINDING PROTEIN, COAGULATION FACTOR X GLA DOMAIN, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: calcium bridging, domain swapping, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Deinagkistrodon acutus (Chinese moccasin); 詳細
• 細胞内の位置: Secreted: P00743
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35478.04

構造登録者

Mizuno, H.,Fujimoto, Z.,Atoda, H.,Morita, T. (登録日: 2001-02-27, 公開日: 2001-06-27, 最終更新日: 2024-04-03)

主引用文献

Mizuno, H.,Fujimoto, Z.,Atoda, H.,Morita, T.
Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X.
Proc.Natl.Acad.Sci.Usa, 98:7230-7234, 2001

PubMed Abstract: The gamma-carboxyglutamic acid (Gla) domain of blood coagulation factors is responsible for Ca2+-dependent phospholipid membrane binding. Factor X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of X-bp in complex with the Gla domain peptide of factor X at 2.3-A resolution showed that the anticoagulation is based on the fact that two patches of the Gla domain essential for membrane binding are buried in the complex formation. The Gla domain thus is expected to be a new target of anticoagulant drugs, and X-bp provides a basis for designing them. This structure also provides a membrane-bound model of factor X.

PubMed: 11404471
DOI: 10.1073/pnas.131179698

実験手法

X-RAY DIFFRACTION (2.3 Å)