1INN

CRYSTAL STRUCTURE OF D. RADIODURANS LUXS, P21

1INN の概要

• エントリーDOI: 10.2210/pdb1inn/pdb
• 分子名称: AUTOINDUCER-2 PRODUCTION PROTEIN LUXS, ZINC ION, METHIONINE, ... (4 entities in total)
• 機能のキーワード: alpha-beta fold, signaling protein
• 由来する生物種: Deinococcus radiodurans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37718.10

構造登録者

Lewis, H.A.,Furlong, E.B.,Bergseid, M.G.,Sanderson, W.E.,Buchanan, S.G. (登録日: 2001-05-14, 公開日: 2001-06-08, 最終更新日: 2017-10-04)

主引用文献

Lewis, H.A.,Furlong, E.B.,Laubert, B.,Eroshkina, G.A.,Batiyenko, Y.,Adams, J.M.,Bergseid, M.G.,Marsh, C.D.,Peat, T.S.,Sanderson, W.E.,Sauder, J.M.,Buchanan, S.G.
A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs.
Structure, 9:527-537, 2001

PubMed Abstract: Quorum sensing is the mechanism by which bacteria control gene expression in response to cell density. Two major quorum-sensing systems have been identified, system 1 and system 2, each with a characteristic signaling molecule (autoinducer-1, or AI-1, in the case of system 1, and AI-2 in system 2). The luxS gene is required for the AI-2 system of quorum sensing. LuxS and AI-2 have been described in both Gram-negative and Gram-positive bacterial species and have been shown to be involved in the expression of virulence genes in several pathogens.

PubMed: 11435117
DOI: 10.1016/S0969-2126(01)00613-X

実験手法

X-RAY DIFFRACTION (1.8 Å)