1ILT

X-RAY STRUCTURE OF INTERLEUKIN-1 RECEPTOR ANTAGONIST AT 2.0 ANGSTROMS RESOLUTION

1ILT の概要

• エントリーDOI: 10.2210/pdb1ilt/pdb
• 分子名称: INTERLEUKIN-1 RECEPTOR ANTAGONIST (1 entity in total)
• 機能のキーワード: cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: P18510
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34290.81

構造登録者

Brandhuber, B.J.,Vigers, G.P.A. (登録日: 1994-03-09, 公開日: 1995-04-01, 最終更新日: 2024-02-07)

主引用文献

Vigers, G.P.,Caffes, P.,Evans, R.J.,Thompson, R.C.,Eisenberg, S.P.,Brandhuber, B.J.
X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution.
J.Biol.Chem., 269:12874-12879, 1994

PubMed Abstract: Interleukin-1 receptor antagonist (IL-1ra) is a natural competitive antagonist of IL-1. In order to further elucidate the mechanism by which IL-1ra binds without activating the IL-1 receptor, we have solved the crystal structure of IL-1ra at 2.0-A resolution. IL-1ra has the same overall beta-trefoil fold as IL-1 alpha and IL-1 beta and has a very similar hydrophobic core. However, there are a number of structural differences between the molecules, including significant differences at the open end of the beta-barrel, which has been identified in IL-1 beta as a receptor binding site.

PubMed: 8175703

実験手法

X-RAY DIFFRACTION (2 Å)