1IJZ

Solution Structure of Human IL-13

1IJZ の概要

• エントリーDOI: 10.2210/pdb1ijz/pdb
• 関連するPDBエントリー: 1IK0
• 分子名称: INTERLEUKIN-13 (1 entity in total)
• 機能のキーワード: left-handed four-helix bundle, cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P35225
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12490.58

構造登録者

Moy, F.J.,Diblasio, E.,Wilhelm, J.,Powers, R. (登録日: 2001-05-01, 公開日: 2002-05-01, 最終更新日: 2024-10-30)

主引用文献

Moy, F.J.,Diblasio, E.,Wilhelm, J.,Powers, R.
Solution structure of human IL-13 and implication for receptor binding.
J.Mol.Biol., 310:219-230, 2001

PubMed Abstract: Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic target. The high-resolution solution structure of human IL-13 has been determined by multidimensional NMR. The resulting structure is consistent with previous short-chain left-handed four-helix bundles, where a significant similarity in the folding topology between IL-13 and IL-4 was observed. IL-13 shares a significant overlap in biological function with IL-4, a result of the common alpha chain component (IL-4Ralpha) in their respective receptors. Based on the available structural and mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodimer is proposed for IL-13.

PubMed: 11419948
DOI: 10.1006/jmbi.2001.4764

実験手法

SOLUTION NMR