1IJ9

Highly Hydrated Human VCAM-1 Fragment

1IJ9 の概要

• エントリーDOI: 10.2210/pdb1ij9/pdb
• 分子名称: VASCULAR CELL ADHESION PROTEIN 1 (2 entities in total)
• 機能のキーワード: integrin solvation, cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P19320
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21893.83

構造登録者

Taylor, P.,Bilsland, M.,Walkinshaw, M.D. (登録日: 2001-04-25, 公開日: 2001-05-02, 最終更新日: 2024-10-30)

主引用文献

Taylor, P.,Bilsland, M.,Walkinshaw, M.D.
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement.
Acta Crystallogr.,Sect.D, 57:1579-1583, 2001

PubMed Abstract: An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.

PubMed: 11679722
DOI: 10.1107/S0907444901011209

実験手法

X-RAY DIFFRACTION (3 Å)