1II4

CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2

Summary for 1II4

• Entry DOI: 10.2210/pdb1ii4/pdb
• Related: 1EV2 1IIL
• Descriptor: HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2 (2 entities in total)
• Functional Keywords: immunoglobulin like domain, b-trefoil, growth factor-growth factor receptor complex, growth factor/growth factor receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• Total number of polymer chains: 8
• Total formula weight: 167959.18

Authors

Ibrahimi, O.A.,Eliseenkova, A.V.,Plotnikov, A.N.,Ornitz, D.M.,Mohammadi, M. (deposition date: 2001-04-20, release date: 2001-05-09, Last modification date: 2023-08-16)

• Primary citation: Ibrahimi, O.A.,Eliseenkova, A.V.,Plotnikov, A.N.,Yu, K.,Ornitz, D.M.,Mohammadi, M.; Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.; Proc.Natl.Acad.Sci.USA, 98:7182-7187, 2001; PubMed: 11390973; DOI: 10.1073/pnas.121183798

Experimental method

X-RAY DIFFRACTION (2.7 Å)