1IH1

Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms

1IH1 の概要

• エントリーDOI: 10.2210/pdb1ih1/pdb
• 関連するPDBエントリー: 1F69 1IH2 1IH3 1IH4 1IH6
• 分子名称: 5'-D(*GP*GP*CP*GP*CP*C)-3', MAGNESIUM ION, COBALT HEXAMMINE(III), ... (4 entities in total)
• 機能のキーワード: b to a dna transition, dna transition, structural transition, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3805.83

構造登録者

Vargason, J.M.,Henderson, K.,Ho, P.S. (登録日: 2001-04-18, 公開日: 2001-06-18, 最終更新日: 2024-02-07)

主引用文献

Vargason, J.M.,Henderson, K.,Ho, P.S.
A crystallographic map of the transition from B-DNA to A-DNA.
Proc.Natl.Acad.Sci.USA, 98:7265-7270, 2001

PubMed Abstract: The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.

PubMed: 11390969
DOI: 10.1073/pnas.121176898

実験手法

X-RAY DIFFRACTION (2 Å)