1IG0

Crystal Structure of yeast Thiamin Pyrophosphokinase

1IG0 の概要

• エントリーDOI: 10.2210/pdb1ig0/pdb
• 分子名称: Thiamin pyrophosphokinase, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM (3 entities in total)
• 機能のキーワード: protein-substrate complex, compound active site, alpha-beta-alpha, beta sandwich, transferase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73848.71

構造登録者

Baker, L.-J.,Dorocke, J.A.,Harris, R.A.,Timm, D.E. (登録日: 2001-04-16, 公開日: 2001-06-20, 最終更新日: 2024-02-07)

主引用文献

Baker, L.J.,Dorocke, J.A.,Harris, R.A.,Timm, D.E.
The crystal structure of yeast thiamin pyrophosphokinase.
Structure, 9:539-546, 2001

PubMed Abstract: Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. TPK has no sequence homologs in the PDB and functions by an unknown mechanism. The TPK structure has been determined as a significant step toward elucidating its catalytic action.

PubMed: 11435118
DOI: 10.1016/S0969-2126(01)00615-3

実験手法

X-RAY DIFFRACTION (1.8 Å)