1IEI
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
Summary for 1IEI
Entry DOI | 10.2210/pdb1iei/pdb |
Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [3-(4-BROMO-2-FLUORO-BENZYL)-7-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-QUINAZOLIN-1-YL]-ACETIC ACID, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, nadp, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37083.38 |
Authors | Kinoshita, T.,Miyake, H.,Fujii, T.,Takakura, S.,Goto, T. (deposition date: 2001-04-09, release date: 2002-04-10, Last modification date: 2024-03-13) |
Primary citation | Kinoshita, T.,Miyake, H.,Fujii, T.,Takakura, S.,Goto, T. The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat. Acta Crystallogr.,Sect.D, 58:622-626, 2002 Cited by PubMed: 11914486DOI: 10.1107/S0907444902002378 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report