1IDO

I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND

1IDO の概要

• エントリーDOI: 10.2210/pdb1ido/pdb
• 分子名称: INTEGRIN, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: integrin, cell adhesion protein, glycoprotein, extracellular matrix, cytoskeleton
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P11215
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21687.01

構造登録者

Lee, J.-O.,Liddington, R. (登録日: 1996-03-12, 公開日: 1996-08-01, 最終更新日: 2024-02-07)

主引用文献

Lee, J.O.,Rieu, P.,Arnaout, M.A.,Liddington, R.
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).
Cell(Cambridge,Mass.), 80:631-638, 1995

PubMed Abstract: We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.

PubMed: 7867070
DOI: 10.1016/0092-8674(95)90517-0

実験手法

X-RAY DIFFRACTION (1.7 Å)