1IDA

CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE

Summary for 1IDA

• Entry DOI: 10.2210/pdb1ida/pdb
• Related: 1IDB
• Related PRD ID: PRD_000340
• Descriptor: Protease, N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide (3 entities in total)
• Functional Keywords: acid proteinase, aids, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 2 (HIV-2)
• Total number of polymer chains: 2
• Total formula weight: 22181.63

Authors

Tong, L.,Anderson, P.C. (deposition date: 1994-10-19, release date: 1995-01-26, Last modification date: 2024-02-07)

• Primary citation: Tong, L.,Pav, S.,Mui, S.,Lamarre, D.,Yoakim, C.,Beaulieu, P.,Anderson, P.C.; Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.; Structure, 3:33-40, 1995; PubMed: 7743130; DOI: 10.1016/S0969-2126(01)00133-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)