1IDA

CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE

1IDA の概要

• エントリーDOI: 10.2210/pdb1ida/pdb
• 関連するPDBエントリー: 1IDB
• 関連するBIRD辞書のPRD_ID: PRD_000340
• 分子名称: Protease, N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide (3 entities in total)
• 機能のキーワード: acid proteinase, aids, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 2 (HIV-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22181.63

構造登録者

Tong, L.,Anderson, P.C. (登録日: 1994-10-19, 公開日: 1995-01-26, 最終更新日: 2024-02-07)

• 主引用文献: Tong, L.,Pav, S.,Mui, S.,Lamarre, D.,Yoakim, C.,Beaulieu, P.,Anderson, P.C.; Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.; Structure, 3:33-40, 1995; PubMed: 7743130; DOI: 10.1016/S0969-2126(01)00133-2

実験手法

X-RAY DIFFRACTION (1.7 Å)