1IDA

CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE

1IDA の概要

• エントリーDOI: 10.2210/pdb1ida/pdb
• 関連するPDBエントリー: 1IDB
• 関連するBIRD辞書のPRD_ID: PRD_000340
• 分子名称: Protease, N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide (3 entities in total)
• 機能のキーワード: acid proteinase, aids, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 2 (HIV-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22181.63

構造登録者

Tong, L.,Anderson, P.C. (登録日: 1994-10-19, 公開日: 1995-01-26, 最終更新日: 2024-02-07)

主引用文献

Tong, L.,Pav, S.,Mui, S.,Lamarre, D.,Yoakim, C.,Beaulieu, P.,Anderson, P.C.
Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.
Structure, 3:33-40, 1995

PubMed Abstract: The HIV protease is essential for the life cycle of the virus and is an important target for the development of therapeutic treatments against AIDS. The structures of HIV protease in complex with different inhibitors have helped in understanding the interactions between inhibitors and the protease and in the design and optimization of HIV protease inhibitors.

PubMed: 7743130
DOI: 10.1016/S0969-2126(01)00133-2

実験手法

X-RAY DIFFRACTION (1.7 Å)