1IAU

HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO

1IAU の概要

• エントリーDOI: 10.2210/pdb1iau/pdb
• 関連するPDBエントリー: 1FI8 1FQ3
• 関連するBIRD辞書のPRD_ID: PRD_000300
• 分子名称: GRANZYME B, acetyl-isoleucyl-glutamyl-prolyl-aspartyl-aldehyde peptide INHIBITOR, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasmic granule: P10144
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27713.42

構造登録者

Rotonda, J.,Garcia-Calvo, M.,Bull, H.G.,Geissler, W.M.,McKeever, B.M.,Willoughby, C.A.,Thornberry, N.A.,Becker, J.W. (登録日: 2001-03-23, 公開日: 2001-05-02, 最終更新日: 2023-11-15)

• 主引用文献: Rotonda, J.,Garcia-Calvo, M.,Bull, H.G.,Geissler, W.M.,McKeever, B.M.,Willoughby, C.A.,Thornberry, N.A.,Becker, J.W.; The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.; Chem.Biol., 8:357-368, 2001; PubMed: 11325591; DOI: 10.1016/S1074-5521(01)00018-7

実験手法

X-RAY DIFFRACTION (2 Å)