1IAR

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX

Summary for 1IAR

• Entry DOI: 10.2210/pdb1iar/pdb
• Descriptor: PROTEIN (INTERLEUKIN-4), PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN) (3 entities in total)
• Functional Keywords: cytokine receptor, interleukin-4, cytokine-receptor complex, cytokine/receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 38727.81

Authors

Hage, T.,Sebald, W.,Reinemer, P. (deposition date: 1999-02-25, release date: 2000-03-03, Last modification date: 2024-10-16)

Primary citation

Hage, T.,Sebald, W.,Reinemer, P.
Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97:271-281, 1999

PubMed Abstract: Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial orientation of the two proteins, a small but unexpected conformational change in the receptor-bound IL-4, and an interface with three separate clusters of trans-interacting residues. Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.

PubMed: 10219247
DOI: 10.1016/S0092-8674(00)80736-9

Experimental method

X-RAY DIFFRACTION (2.3 Å)