1IAR

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX

1IAR の概要

• エントリーDOI: 10.2210/pdb1iar/pdb
• 分子名称: PROTEIN (INTERLEUKIN-4), PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN) (3 entities in total)
• 機能のキーワード: cytokine receptor, interleukin-4, cytokine-receptor complex, cytokine/receptor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38727.81

構造登録者

Hage, T.,Sebald, W.,Reinemer, P. (登録日: 1999-02-25, 公開日: 2000-03-03, 最終更新日: 2024-10-16)

主引用文献

Hage, T.,Sebald, W.,Reinemer, P.
Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97:271-281, 1999

PubMed Abstract: Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial orientation of the two proteins, a small but unexpected conformational change in the receptor-bound IL-4, and an interface with three separate clusters of trans-interacting residues. Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.

PubMed: 10219247
DOI: 10.1016/S0092-8674(00)80736-9

実験手法

X-RAY DIFFRACTION (2.3 Å)