1I85

CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX

Summary for 1I85

• Entry DOI: 10.2210/pdb1i85/pdb
• Descriptor: T LYMPHOCYTE ACTIVATION ANTIGEN CD86, CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 (2 entities in total)
• Functional Keywords: ig v-type domain, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P42081 P16410
• Total number of polymer chains: 4
• Total formula weight: 52719.94

Authors

Schwartz, J.-C.D.,Zhang, X.,Fedorov, A.A.,Nathenson, S.G.,Almo, S.C. (deposition date: 2001-03-12, release date: 2001-04-04, Last modification date: 2011-07-13)

• Primary citation: Schwartz, J.C.,Zhang, X.,Fedorov, A.A.,Nathenson, S.G.,Almo, S.C.; Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.; Nature, 410:604-608, 2001; PubMed: 11279501; DOI: 10.1038/35069112

Experimental method

X-RAY DIFFRACTION (3.2 Å)