1I72
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE
Summary for 1I72
Entry DOI | 10.2210/pdb1i72/pdb |
Related | 1I79 1I7B 1I7C 1I7M 1JEN |
Descriptor | S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE, ... (5 entities in total) |
Functional Keywords | spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 38794.04 |
Authors | Tolbert, W.D.,Ekstrom, J.L.,Mathews, I.I.,Secrist III, J.A.,Pegg, A.E.,Ealick, S.E. (deposition date: 2001-03-07, release date: 2001-08-22, Last modification date: 2023-11-15) |
Primary citation | Tolbert, W.D.,Ekstrom, J.L.,Mathews, I.I.,Secrist III, J.A.,Kapoor, P.,Pegg, A.E.,Ealick, S.E. The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. Biochemistry, 40:9484-9494, 2001 Cited by PubMed: 11583147DOI: 10.1021/bi010735w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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