1I5R

TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EM1745 COMPLEX

Summary for 1I5R

• Entry DOI: 10.2210/pdb1i5r/pdb
• Related: 1IOL
• Descriptor: TYPE 1 17 BETA-HYDROXYSTEROID DEHYDROGENASE, O5'-[9-(3,17B-DIHYDROXY-1,3,5(10)-ESTRATRIEN-16B-YL)-NONANOYL]ADENOSINE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: dehydrogenase, 17beta-hydroxysteroid, hybrid, inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14061
• Total number of polymer chains: 1
• Total formula weight: 35841.94

Authors

Qiu, W.,Campbell, R.L.,Boivin, P.,Poirier, D.,Lin, S.-X. (deposition date: 2001-02-28, release date: 2003-03-11, Last modification date: 2023-08-09)

• Primary citation: Qiu, W.,Campbell, R.L.,Gangloff, A.,Dupuis, P.,Boivin, R.P.,Tremblay, M.R.,Poirier, D.,Lin, S.X.; A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity; FASEB J., 16:1829-1831, 2002; PubMed: 12223444

Experimental method

X-RAY DIFFRACTION (1.6 Å)