1I05

CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE

1I05 の概要

• エントリーDOI: 10.2210/pdb1i05/pdb
• 関連するPDBエントリー: 1IO4 1IO6 1MUP
• 分子名称: MAJOR URINARY PROTEIN I, CADMIUM ION, 6-HYDROXY-6-METHYL-HEPTAN-3-ONE, ... (4 entities in total)
• 機能のキーワード: lipocalin, beta-barrel, pheromone, transport protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21605.48

構造登録者

Timm, D.E.,Baker, L.J.,Mueller, H.,Zidek, L.,Novotny, M.V. (登録日: 2001-01-28, 公開日: 2001-02-14, 最終更新日: 2024-11-06)

主引用文献

Timm, D.E.,Baker, L.J.,Mueller, H.,Zidek, L.,Novotny, M.V.
Structural Basis of Pheromone Binding to Mouse Major Urinary Protein (MUP-I)
Protein Sci., 10:997-1004, 2001

PubMed Abstract: The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.

PubMed: 11316880
DOI: 10.1110/ps.52201

実験手法

X-RAY DIFFRACTION (2 Å)