1HZZ

THE ASYMMETRIC COMPLEX OF THE TWO NUCLEOTIDE-BINDING COMPONENTS (DI, DIII) OF PROTON-TRANSLOCATING TRANSHYDROGENASE

1HZZ の概要

• エントリーDOI: 10.2210/pdb1hzz/pdb
• 関連するPDBエントリー: 1DJL 1E3T 1F8G
• 分子名称: PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA, PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTB, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: rossmann fold, alpha beta repeat, nucleotide-binding fold, oxidoreductase
• 由来する生物種: Rhodospirillum rubrum; 詳細
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein (By similarity): Q59765
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 103541.91

構造登録者

Cotton, N.P.J.,White, S.A.,Peake, S.J.,McSweeney, S.,Jackson, J.B. (登録日: 2001-01-27, 公開日: 2001-08-29, 最終更新日: 2024-02-07)

主引用文献

Cotton, N.P.,White, S.A.,Peake, S.J.,McSweeney, S.,Jackson, J.B.
The crystal structure of an asymmetric complex of the two nucleotide binding components of proton-translocating transhydrogenase.
Structure, 9:165-176, 2001

PubMed Abstract: Membrane-bound ion translocators have important functions in biology, but their mechanisms of action are often poorly understood. Transhydrogenase, found in animal mitochondria and bacteria, links the redox reaction between NAD(H) and NADP(H) to proton translocation across a membrane. Linkage is achieved through changes in protein conformation at the nucleotide binding sites. The redox reaction takes place between two protein components located on the membrane surface: dI, which binds NAD(H), and dIII, which binds NADP(H). A third component, dII, provides a proton channel through the membrane. Intact membrane-located transhydrogenase is probably a dimer (two copies each of dI, dII, and dIII).

PubMed: 11250201
DOI: 10.1016/S0969-2126(01)00571-8

実験手法

X-RAY DIFFRACTION (2.5 Å)