1HY9

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT

Summary for 1HY9

• Entry DOI: 10.2210/pdb1hy9/pdb
• Descriptor: COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN (1 entity in total)
• Functional Keywords: cysteine knot, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 4399.22

Authors

Ludvigsen, S.,Thim, L.,Blom, A.M.,Wulff, B.S. (deposition date: 2001-01-18, release date: 2001-08-29, Last modification date: 2024-10-30)

Primary citation

Ludvigsen, S.,Thim, L.,Blom, A.M.,Wulff, B.S.
Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.
Biochemistry, 40:9082-9088, 2001

PubMed Abstract: Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges CART(48-89) is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots.

PubMed: 11478874
DOI: 10.1021/bi010433u

Experimental method

SOLUTION NMR