1HVS

STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING

1HVS の概要

• エントリーDOI: 10.2210/pdb1hvs/pdb
• 分子名称: HIV-1 PROTEASE, N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE (2 entities in total)
• 機能のキーワード: hydrolase (acid protease)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22346.38

構造登録者

Baldwin, E.T.,Bhat, T.N.,Liu, B.,Pattabiraman, N.,Erickson, J.W. (登録日: 1994-11-17, 公開日: 1995-02-14, 最終更新日: 2024-02-07)

• 主引用文献: Baldwin, E.T.,Bhat, T.N.,Liu, B.,Pattabiraman, N.,Erickson, J.W.; Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase.; Nat.Struct.Biol., 2:244-249, 1995; PubMed: 7773792; DOI: 10.1038/nsb0395-244

実験手法

X-RAY DIFFRACTION (2.25 Å)