1HV7

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

1HV7 の概要

• エントリーDOI: 10.2210/pdb1hv7/pdb
• 分子名称: ELASTASE 1, SULFATE ION, N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: serine protease-inhibitor complex, hydrolase
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Secreted: P00772
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26424.63

構造登録者

Skarzynski, T.,Singh, O.M. (登録日: 2001-01-08, 公開日: 2001-01-17, 最終更新日: 2024-11-13)

主引用文献

Macdonald, S.J.,Dowle, M.D.,Harrison, L.A.,Shah, P.,Johnson, M.R.,Inglis, G.G.,Clarke, G.D.,Smith, R.A.,Humphreys, D.,Molloy, C.R.,Amour, A.,Dixon, M.,Murkitt, G.,Godward, R.E.,Padfield, T.,Skarzynski, T.,Singh, O.M.,Kumar, K.A.,Fleetwood, G.,Hodgson, S.T.,Hardy, G.W.,Finch, H.
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate
Bioorg.Med.Chem.Lett., 11:895-898, 2001

PubMed Abstract: The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.

PubMed: 11294386
DOI: 10.1016/S0960-894X(01)00078-6

実験手法

X-RAY DIFFRACTION (1.7 Å)