1HTM

STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION

1HTM の概要

• エントリーDOI: 10.2210/pdb1htm/pdb
• 分子名称: HEMAGGLUTININ HA1 CHAIN, HEMAGGLUTININ HA2 CHAIN (3 entities in total)
• 機能のキーワード: influenza virus hemagglutinin, viral protein
• 由来する生物種: uncultured beta proteobacterium UMTRA-608; 詳細
• 細胞内の位置: Virion membrane; Single-pass type I membrane protein (Potential): P03437 P03437
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 57132.57

構造登録者

Bullough, P.A.,Hughson, F.M.,Skehel, J.J.,Wiley, D.C. (登録日: 1994-11-02, 公開日: 1995-02-14, 最終更新日: 2024-10-30)

主引用文献

Bullough, P.A.,Hughson, F.M.,Skehel, J.J.,Wiley, D.C.
Structure of influenza haemagglutinin at the pH of membrane fusion.
Nature, 371:37-43, 1994

PubMed Abstract: Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.

PubMed: 8072525
DOI: 10.1038/371037a0

実験手法

X-RAY DIFFRACTION (2.5 Å)