1HTE

X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE

1HTE の概要

• エントリーDOI: 10.2210/pdb1hte/pdb
• 分子名称: HIV-1 PROTEASE, (2R,4S)-2-[(R)-BENZYLCARBAMOYL-PHENYLACETYL-METHYL]-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: hydrolase(acid proteinase)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22524.55

構造登録者

Jhoti, H.,Wonacott, A.,Murray-Rust, P. (登録日: 1994-04-29, 公開日: 1994-07-31, 最終更新日: 2024-02-07)

• 主引用文献: Jhoti, H.,Singh, O.M.,Weir, M.P.,Cooke, R.,Murray-Rust, P.,Wonacott, A.; X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease.; Biochemistry, 33:8417-8427, 1994; PubMed: 8031777; DOI: 10.1021/bi00194a005

実験手法

X-RAY DIFFRACTION (2.8 Å)