1HSI
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Summary for 1HSI
Entry DOI | 10.2210/pdb1hsi/pdb |
Descriptor | HIV-2 PROTEASE (2 entities in total) |
Functional Keywords | hydrolase (acid proteinase) |
Biological source | Human immunodeficiency virus 2 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584 |
Total number of polymer chains | 2 |
Total formula weight | 21456.67 |
Authors | Chen, Z. (deposition date: 1995-03-31, release date: 1996-04-03, Last modification date: 2024-02-07) |
Primary citation | Chen, Z.,Li, Y.,Chen, E.,Hall, D.L.,Darke, P.L.,Culberson, C.,Shafer, J.A.,Kuo, L.C. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J.Biol.Chem., 269:26344-26348, 1994 Cited by PubMed: 7929352PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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