1HRP

CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

1HRP の概要

• エントリーDOI: 10.2210/pdb1hrp/pdb
• 分子名称: HUMAN CHORIONIC GONADOTROPIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: hormone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27059.94

構造登録者

Lapthorn, A.J.,Harris, D.C.,Isaacs, N.W. (登録日: 1994-08-15, 公開日: 1994-11-01, 最終更新日: 2024-10-30)

主引用文献

Lapthorn, A.J.,Harris, D.C.,Littlejohn, A.,Lustbader, J.W.,Canfield, R.E.,Machin, K.J.,Morgan, F.J.,Isaacs, N.W.
Crystal structure of human chorionic gonadotropin.
Nature, 369:455-461, 1994

PubMed Abstract: The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.

PubMed: 8202136
DOI: 10.1038/369455a0

実験手法

X-RAY DIFFRACTION (3 Å)