1HP3

C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)

1HP3 の概要

• エントリーDOI: 10.2210/pdb1hp3/pdb
• 関連するPDBエントリー: 1G9P
• 分子名称: OMEGA-ATRACOTOXIN-HV2A (1 entity in total)
• 機能のキーワード: cystine knot, toxin
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3383.95

構造登録者

Wang, X.-H.,King, G.F. (登録日: 2000-12-12, 公開日: 2002-12-11, 最終更新日: 2024-11-13)

主引用文献

Wang, X.-H.,Connor, M.,Wilson, D.,Wilson, H.I.,Nicholson, G.M.,Smith, R.,Shaw, D.,Mackay, J.P.,Alewood, P.F.,Christie, M.J.,King, G.F.
Discovery and structure of a potent and highly specific blocker of insect calcium channels
J.Biol.Chem., 276:40306-40312, 2001

PubMed Abstract: We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.

PubMed: 11522785

実験手法

SOLUTION NMR