1HO1

CRYSTAL STRUCTURE OF PYRIDOXINE 5'-PHOSPHATE SYNTHASE

1HO1 の概要

• エントリーDOI: 10.2210/pdb1ho1/pdb
• 関連するPDBエントリー: 1HO4
• 分子名称: PYRIDOXINE 5'-PHOSPHATE SYNTHASE (2 entities in total)
• 機能のキーワード: tim barrel, biosynthetic protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A794
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 105160.57

構造登録者

Garrido-Franco, M.,Laber, B.,Huber, R.,Clausen, T. (登録日: 2000-12-08, 公開日: 2001-03-28, 最終更新日: 2024-02-07)

主引用文献

Franco, M.G.,Laber, B.,Huber, R.,Clausen, T.
Structural basis for the function of pyridoxine 5'-phosphate synthase.
Structure, 9:245-253, 2001

PubMed Abstract: Pyridoxal 5'-phosphate is the active form of vitamin B(6) that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In Escherichia coli, the pathway of the de novo biosynthesis of vitamin B(6) results in the formation of pyridoxine 5'-phosphate (PNP), which can be regarded as the first synthesized B(6) vitamer. PNP synthase (commonly referred to as PdxJ) is a homooctameric enzyme that catalyzes the final step in this pathway, a complex intramolecular condensation reaction between 1-deoxy-D-xylulose-5'-phosphate and 1-amino-acetone-3-phosphate.

PubMed: 11286891
DOI: 10.1016/S0969-2126(01)00584-6

実験手法

X-RAY DIFFRACTION (2 Å)