1HNN

CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)

1HNN の概要

• エントリーDOI: 10.2210/pdb1hnn/pdb
• 分子名称: PHENYLETHANOLAMINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-SULFONIC ACID AMIDE, ... (4 entities in total)
• 機能のキーワード: methyltransferase, adrenaline synthesis, s-adenosyl methionine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62969.32

構造登録者

Martin, J.L.,Begun, J.,McLeish, M.J.,Caine, J.M.,Grunewald, G.L. (登録日: 2000-12-07, 公開日: 2001-12-07, 最終更新日: 2024-02-07)

主引用文献

Martin, J.L.,Begun, J.,McLeish, M.J.,Caine, J.M.,Grunewald, G.L.
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.
Structure, 9:977-985, 2001

PubMed Abstract: Adrenaline is localized to specific regions of the central nervous system (CNS), but its role therein is unclear because of a lack of suitable pharmacologic agents. Ideally, a chemical is required that crosses the blood-brain barrier, potently inhibits the adrenaline-synthesizing enzyme PNMT, and does not affect other catecholamine processes. Currently available PNMT inhibitors do not meet these criteria. We aim to produce potent, selective, and CNS-active PNMT inhibitors by structure-based design methods. The first step is the structure determination of PNMT.

PubMed: 11591352
DOI: 10.1016/S0969-2126(01)00662-1

実験手法

X-RAY DIFFRACTION (2.4 Å)