1HNG

CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2

Summary for 1HNG

• Entry DOI: 10.2210/pdb1hng/pdb
• Descriptor: CD2 (1 entity in total)
• Functional Keywords: t lymphocyte adhesion glycoprotein
• Biological source: Rattus rattus (black rat)
• Cellular location: Membrane; Single-pass type I membrane protein: P08921
• Total number of polymer chains: 2
• Total formula weight: 40276.04

Authors

Jones, E.Y.,Davis, S.J.,Williams, A.F.,Harlos, K.,Stuart, D.I. (deposition date: 1994-08-10, release date: 1995-02-07, Last modification date: 2024-10-30)

Primary citation

Jones, E.Y.,Davis, S.J.,Williams, A.F.,Harlos, K.,Stuart, D.I.
Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Nature, 360:232-239, 1992

PubMed Abstract: The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

PubMed: 1279440
DOI: 10.1038/360232a0

Experimental method

X-RAY DIFFRACTION (2.8 Å)