1HNG

CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2

1HNG の概要

• エントリーDOI: 10.2210/pdb1hng/pdb
• 分子名称: CD2 (1 entity in total)
• 機能のキーワード: t lymphocyte adhesion glycoprotein
• 由来する生物種: Rattus rattus (black rat)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08921
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40276.04

構造登録者

Jones, E.Y.,Davis, S.J.,Williams, A.F.,Harlos, K.,Stuart, D.I. (登録日: 1994-08-10, 公開日: 1995-02-07, 最終更新日: 2024-10-30)

主引用文献

Jones, E.Y.,Davis, S.J.,Williams, A.F.,Harlos, K.,Stuart, D.I.
Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Nature, 360:232-239, 1992

PubMed Abstract: The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

PubMed: 1279440
DOI: 10.1038/360232a0

実験手法

X-RAY DIFFRACTION (2.8 Å)