1HMA

THE SOLUTION STRUCTURE AND DYNAMICS OF THE DNA BINDING DOMAIN OF HMG-D FROM DROSOPHILA MELANOGASTER

1HMA の概要

• エントリーDOI: 10.2210/pdb1hma/pdb
• 分子名称: HMG-D (1 entity in total)
• 機能のキーワード: dna-binding
• 由来する生物種: Drosophila melanogaster (fruit fly)
• 細胞内の位置: Nucleus: Q05783
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8370.51

構造登録者

Jones, D.N.M.,Searles, M.A.,Shaw, G.L.,Churchill, M.E.A.,Ner, S.S.,Keeler, J.,Travers, A.A.,Neuhaus, D. (登録日: 1994-05-12, 公開日: 1994-07-31, 最終更新日: 2024-05-22)

主引用文献

Jones, D.N.,Searles, M.A.,Shaw, G.L.,Churchill, M.E.,Ner, S.S.,Keeler, J.,Travers, A.A.,Neuhaus, D.
The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster.
Structure, 2:609-627, 1994

PubMed Abstract: The HMG-box is a conserved DNA-binding motif that has been identified in many high mobility group (HMG) proteins. HMG-D is a non-histone chromosomal protein from Drosophila melanogaster that is closely related to the mammalian HMG-box proteins HMG-1 and HMG-2. Previous structures determined for an HMG-box domain from rat and hamster exhibit the same global topology, but differ significantly in detail. It has been suggested that these differences may arise from hinge motions which allow the protein to adapt to the shape of its target DNA.

PubMed: 7922039
DOI: 10.1016/S0969-2126(00)00063-0

実験手法

SOLUTION NMR