1HLA

STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2

1HLA の概要

• エントリーDOI: 10.2210/pdb1hla/pdb
• 関連するPDBエントリー: 3HLA
• 分子名称: CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2) (ALPHA CHAIN), BETA 2-MICROGLOBULIN (2 entities in total)
• 機能のキーワード: histocompatibility antigen
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42669.30

構造登録者

Bjorkman, P.J.,Saper, M.A.,Samraoui, B.,Bennett, W.S.,Strominger, J.L.,Wiley, D.C. (登録日: 1987-10-15, 公開日: 1988-01-16, 最終更新日: 2024-02-07)

主引用文献

Bjorkman, P.J.,Saper, M.A.,Samraoui, B.,Bennett, W.S.,Strominger, J.L.,Wiley, D.C.
Structure of the human class I histocompatibility antigen, HLA-A2.
Nature, 329:506-512, 1987

PubMed Abstract: The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

PubMed: 3309677
DOI: 10.1038/329506a0

実験手法

X-RAY DIFFRACTION (3.5 Å)