1HJF

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258

Summary for 1HJF

Entry DOI	10.2210/pdb1hjf/pdb
Related	1DCS 1E5H 1E5I 1HJG 1RXF 1RXG
Descriptor	DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION, 2-OXO-4-METHYLPENTANOIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, alternative 2-oxoacids, cephem antibiotic biosynthesis, chemical cosubstrate rescue, co-substrate selectivity, 2- oxoglutarate-dependent oxygenase
Biological source	STREPTOMYCES CLAVULIGERUS
Total number of polymer chains	1
Total formula weight	34748.56
Authors	Lee, H.J.,Lloyd, M.D.,Clifton, I.J.,Harlos, K.,Dubus, A.,Baldwin, J.E.,Frere, J.M.,Schofield, C.J. (deposition date: 2001-01-15, release date: 2001-06-01, Last modification date: 2023-12-13)
Primary citation	Lee, H.J.,Lloyd, M.D.,Harlos, K.,Clifton, I.J.,Baldwin, J.E.,Schofield, C.J. Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258 J.Biol.Chem., 276:18290-, 2001 Cited by PubMed: 11279000 DOI: 10.1074/JBC.M100085200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation