1HIA

KALLIKREIN COMPLEXED WITH HIRUSTASIN

1HIA の概要

• エントリーDOI: 10.2210/pdb1hia/pdb
• 分子名称: KALLIKREIN, HIRUSTASIN, ... (4 entities in total)
• 機能のキーワード: complex (protease-inhibitor), tissue kallikrein, serine protease, trypsin, psa, kinin, serpin, complex (protease-inhibitor) complex, complex (protease/inhibitor)
• 由来する生物種: Sus scrofa (pig); 詳細
• 細胞内の位置: Secreted: P80302
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 61661.45

構造登録者

Mittl, P.,Di Marco, S.,Gruetter, M. (登録日: 1996-12-12, 公開日: 1997-12-24, 最終更新日: 2024-10-23)

主引用文献

Mittl, P.R.,Di Marco, S.,Fendrich, G.,Pohlig, G.,Heim, J.,Sommerhoff, C.,Fritz, H.,Priestle, J.P.,Grutter, M.G.
A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex.
Structure, 5:253-264, 1997

PubMed Abstract: Hirustasin belongs to a class of serine protease inhibitors characterized by a well conserved pattern of cysteine residues. Unlike the closely related inhibitors, antistasin/ghilanten and guamerin, which are selective for coagulation factor Xa or neutrophil elastase, hirustasin binds specifically to tissue kallikrein. The conservation of the pattern of cysteine residues and the significant sequence homology suggest that these related inhibitors possess a similar three-dimensional structure to hirustasin.

PubMed: 9032072
DOI: 10.1016/S0969-2126(97)00183-4

実験手法

X-RAY DIFFRACTION (2.4 Å)