1HFR

COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

1HFR の概要

• エントリーDOI: 10.2210/pdb1hfr/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, one-carbon metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22537.37

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A. (登録日: 1997-11-04, 公開日: 1998-01-28, 最終更新日: 2024-02-07)

• 主引用文献: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A.; Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.; Anti-Cancer Drug Des., 13:307-315, 1998; PubMed: 9627670

実験手法

X-RAY DIFFRACTION (2.1 Å)