1HFP
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Summary for 1HFP
Entry DOI | 10.2210/pdb1hfp/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, one-carbon metabolism |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22447.25 |
Authors | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A. (deposition date: 1997-11-04, release date: 1998-01-28, Last modification date: 2024-02-07) |
Primary citation | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A. Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Anti-Cancer Drug Des., 13:307-315, 1998 Cited by PubMed: 9627670PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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