1HDH

Arylsulfatase from Pseudomonas aeruginosa

1HDH の概要

• エントリーDOI: 10.2210/pdb1hdh/pdb
• 分子名称: Arylsulfatase, CALCIUM ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, sulfatase, formylglycine hydrate
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120887.74

構造登録者

Boltes, I.,Czapinska, H.,Kahnert, A.,von Buelow, R.,Dirks, T.,Schmidt, B.,von Figura, K.,Kertesz, M.A.,Uson, I. (登録日: 2000-11-16, 公開日: 2001-11-15, 最終更新日: 2024-10-16)

主引用文献

Boltes, I.,Czapinska, H.,Kahnert, A.,von Buelow, R.,Dirks, T.,Schmidt, B.,von Figura, K.,Kertesz, M.A.,Uson, I.
1.3 A Structure of Arylsulfatase from Pseudomonas Aeruginosa Establishes the Catalytic Mechanism of Sulfate Ester Cleavage in the Sulfatase Family.
Structure, 9:483-491, 2001

PubMed Abstract: Sulfatases constitute a family of enzymes with a highly conserved active site region including a Calpha-formylglycine that is posttranslationally generated by the oxidation of a conserved cysteine or serine residue. The crystal structures of two human arylsulfatases, ASA and ASB, along with ASA mutants and their complexes led to different proposals for the catalytic mechanism in the hydrolysis of sulfate esters.

PubMed: 11435113
DOI: 10.1016/S0969-2126(01)00609-8

実験手法

X-RAY DIFFRACTION (1.3 Å)