1HAR

2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)

1HAR の概要

• エントリーDOI: 10.2210/pdb1har/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS) (2 entities in total)
• 機能のキーワード: reverse transcriptase, viral protein, transferase, dna polymerase, fingers-palm subdomains, n-terminal half
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24261.10

構造登録者

Unge, T.,Knight, S.,Strandberg, B. (登録日: 1994-10-28, 公開日: 1995-04-20, 最終更新日: 2024-02-07)

主引用文献

Unge, T.,Knight, S.,Bhikhabhai, R.,Lovgren, S.,Dauter, Z.,Wilson, K.,Strandberg, B.
2.2 A resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains).
Structure, 2:953-961, 1994

PubMed Abstract: HIV-1 reverse transcriptase (RT) catalyzes the transformation of single-stranded viral RNA into double-stranded DNA, which is integrated into host cell chromosomes. The molecule is a heterodimer of two subunits, p51 and p66. The amino acid sequence of p51 is identical to the sequence of the amino-terminal subdomains of p66. Earlier crystallographic studies indicate that the RT molecule is flexible, which may explain the difficulty in obtaining high-resolution data for the intact protein. We have therefore determined the structure of a fragment of RT (RT216), which contains only the amino-terminal half of the RT molecule ('finger' and 'palm' subdomains).

PubMed: 7532533
DOI: 10.1016/S0969-2126(94)00097-2

実験手法

X-RAY DIFFRACTION (2.2 Å)