1H9F

LEM DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2

1H9F の概要

• エントリーDOI: 10.2210/pdb1h9f/pdb
• 関連するPDBエントリー: 1H9E
• NMR情報: BMRB: 5043
• 分子名称: Lamina-associated polypeptide 2, isoform alpha (1 entity in total)
• 機能のキーワード: membrane protein, inner nuclear membrane protein, lamina-associated polypeptide, emerin, lem domain
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6543.31

構造登録者

Laguri, C.,Gilquin, B.,Wolff, N.,Romi-Lebrun, R.,Courchay, K.,Callebaut, I.,Worman, H.J.,Zinn-Justin, S. (登録日: 2001-03-09, 公開日: 2001-06-17, 最終更新日: 2024-05-15)

主引用文献

Laguri, C.,Gilquin, B.,Wolff, N.,Romi-Lebrun, R.,Courchay, K.,Callebaut, I.,Worman, H.J.,Zinn-Justin, S.
Structural Characterization of the Lem Motif Common to Three Human Inner Nuclear Membrane Proteins
Structure, 9:503-, 2001

PubMed Abstract: Integral membrane proteins of the inner nuclear membrane are involved in chromatin organization and postmitotic reassembly of the nucleus. The discovery that mutations in the gene encoding emerin causes X-linked Emery-Dreifuss muscular dystrophy has enhanced interest in such proteins. A common structural domain of 50 residues, called the LEM domain, has been identified in emerin MAN1, and lamina-associated polypeptide (LAP) 2. In particular, all LAP2 isoforms share an N-terminal segment composed of such a LEM domain that is connected to a highly divergent LEM-like domain by a linker that is probably unstructured.

PubMed: 11435115
DOI: 10.1016/S0969-2126(01)00611-6

実験手法

SOLUTION NMR