1H8M

Solution structure of ykt6

Summary for 1H8M

Entry DOI	10.2210/pdb1h8m/pdb
Descriptor	SYNAPTOBREVIN HOMOLOG 1 (1 entity in total)
Functional Keywords	endocytosis/exocytosis, transmembrane lipoprotein, prenylation, endocytosis-exocytosis complex
Biological source	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Total number of polymer chains	1
Total formula weight	15854.74
Authors	Tochio, H.,Tsui, M.M.K.,Banfield, D.K.,Zhang, M. (deposition date: 2001-02-10, release date: 2001-08-07, Last modification date: 2024-05-15)
Primary citation	Tochio, H.,Tsui, M.M.K.,Banfield, D.K.,Zhang, M. An Autoinhibitory Mechanism for Nonsyntaxin Snare Proteins Revealed by the Structure of Ykt6P Science, 293:698-, 2001 Cited by PubMed Abstract: Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes. PubMed: 11474112 DOI: 10.1126/SCIENCE.1062950 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation