1H8M

Solution structure of ykt6

1H8M の概要

• エントリーDOI: 10.2210/pdb1h8m/pdb
• 分子名称: SYNAPTOBREVIN HOMOLOG 1 (1 entity in total)
• 機能のキーワード: endocytosis/exocytosis, transmembrane lipoprotein, prenylation, endocytosis-exocytosis complex
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15854.74

構造登録者

Tochio, H.,Tsui, M.M.K.,Banfield, D.K.,Zhang, M. (登録日: 2001-02-10, 公開日: 2001-08-07, 最終更新日: 2024-05-15)

主引用文献

Tochio, H.,Tsui, M.M.K.,Banfield, D.K.,Zhang, M.
An Autoinhibitory Mechanism for Nonsyntaxin Snare Proteins Revealed by the Structure of Ykt6P
Science, 293:698-, 2001

PubMed Abstract: Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.

PubMed: 11474112
DOI: 10.1126/SCIENCE.1062950

実験手法

SOLUTION NMR