1H8B
EF-hands 3,4 from alpha-actinin / Z-repeat 7 from titin
Summary for 1H8B
| Entry DOI | 10.2210/pdb1h8b/pdb |
| Descriptor | ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM, TITIN (2 entities in total) |
| Functional Keywords | structural protein, z-disk structural complex |
| Biological source | HOMO SAPIENS (HUMAN) More |
| Cellular location | Cytoplasm, myofibril, sarcomere, Z line: P35609 |
| Total number of polymer chains | 2 |
| Total formula weight | 13744.33 |
| Authors | Atkinson, R.A.,Joseph, C.,Kelly, G.,Muskett, F.W.,Frenkiel, T.A.,Nietlispach, D.,Pastore, A. (deposition date: 2001-02-01, release date: 2001-08-30, Last modification date: 2024-05-15) |
| Primary citation | Atkinson, R.A.,Joseph, C.,Kelly, G.,Muskett, F.W.,Frenkiel, T.A.,Nietlispach, D.,Pastore, A. Ca2+-Independent Binding of an EF-Hand Domain to a Novel Motif in the Alpha-Actinin-Titin Complex Nat.Struct.Biol., 8:853-, 2001 Cited by PubMed Abstract: The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains. PubMed: 11573089DOI: 10.1038/NSB1001-853 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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