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1H31

Oxidised SoxAX complex from Rhodovulum sulfidophilum

1H31 の概要
エントリーDOI10.2210/pdb1h31/pdb
分子名称DIHEME CYTOCHROME C, CYTOCHROME C, HEME C, ... (4 entities in total)
機能のキーワードelectron transport, sulfur cycle, soxax complex, thiosulfate oxidation, cysteine persulfide heme ligand
由来する生物種RHODOVULUM SULFIDOPHILUM
詳細
タンパク質・核酸の鎖数8
化学式量合計182346.66
構造登録者
Bamford, V.A.,Bruno, S.,Rasmussen, T.,Appia-Ayme, C.,Cheesman, M.R.,Berks, B.C.,Hemmings, A.M. (登録日: 2002-08-21, 公開日: 2002-11-07, 最終更新日: 2013-03-06)
主引用文献Bamford, V.A.,Bruno, S.,Rasmussen, T.,Appia-Ayme, C.,Cheesman, M.R.,Berks, B.C.,Hemmings, A.M.
Structural Basis for the Oxidation of Thiosulfate by a Sulfur Cycle Enzyme
Embo J., 21:5599-, 2002
Cited by
PubMed Abstract: Reduced inorganic sulfur compounds are utilized by many bacteria as electron donors to photosynthetic or respiratory electron transport chains. This metabolism is a key component of the biogeochemical sulfur cycle. The SoxAX protein is a heterodimeric c-type cytochrome involved in thiosulfate oxidation. The crystal structures of SoxAX from the photosynthetic bacterium Rhodovulum sulfidophilum have been solved at 1.75 A resolution in the oxidized state and at 1.5 A resolution in the dithionite-reduced state, providing the first structural insights into the enzymatic oxidation of thiosulfate. The SoxAX active site contains a haem with unprecedented cysteine persulfide (cysteine sulfane) coordination. This unusual post-translational modification is also seen in sulfurtransferases such as rhodanese. Intriguingly, this enzyme shares further active site characteristics with SoxAX such as an adjacent conserved arginine residue and a strongly positive electrostatic potential. These similarities have allowed us to suggest a catalytic mechanism for enzymatic thiosulfate oxidation. The atomic coordinates and experimental structure factors have been deposited in the PDB with the accession codes 1H31, 1H32 and 1H33.
PubMed: 12411478
DOI: 10.1093/EMBOJ/CDF566
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.55 Å)
構造検証レポート
Validation report summary of 1h31
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-10-30に公開中

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