1GYF

GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN

1GYF の概要

• エントリーDOI: 10.2210/pdb1gyf/pdb
• 分子名称: PROTEIN (CYTOPLASMIC DOMAIN BINDING PROTEIN (CD2BP2)) (1 entity in total)
• 機能のキーワード: t cell signaling, proline-rich sequence recognition, adapter domain, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7320.01

構造登録者

Freund, C.,Doetsch, V.,Nishizawa, K.,Reinherz, E.L.,Wagner, G. (登録日: 1999-04-30, 公開日: 2000-01-05, 最終更新日: 2023-12-27)

主引用文献

Freund, C.,Dotsch, V.,Nishizawa, K.,Reinherz, E.L.,Wagner, G.
The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.
Nat.Struct.Biol., 6:656-660, 1999

PubMed Abstract: T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail. A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2. We solved the solution structure of the CD2 binding domain of CD2BP2, which we name the glycine-tyrosine-phenylalanine (GYF) domain. The GYF sequence is part of a structurally unique bulge-helix-bulge motif that constitutes the major binding site for the CD2 tail. A hydrophobic surface patch is created by motif residues that are highly conserved among a variety of proteins from diverse eukaryotic species. Thus, the architecture of the GYF domain may be widely used in protein-protein associations.

PubMed: 10404223
DOI: 10.1038/10712

実験手法

SOLUTION NMR